概述

产品描述	Rabbit Polyclonal antibody recognizes ARHGEF7
反应物种	Hu, Ms
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	ARHGEF7
抗原物种	Human
抗原	Recombinant Protein of Human ARHGEF7.
偶联标记	Un-conjugated
別名	PAK-interacting exchange factor beta; COOL-1; COOL1; P50BP; BETA-PIX; Rho guanine nucleotide exchange factor 7; P85; P85SPR; P85COOL1; p85; Nbla10314; PAK3; P50; Beta-Pix; PIXB

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Jurkat

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 54126 Mouse ARHGEF7 GeneID: 8874 Human ARHGEF7 Swiss-port # Q14155 Human Rho guanine nucleotide exchange factor 7 Swiss-port # Q9ES28 Mouse Rho guanine nucleotide exchange factor 7
基因名称	ARHGEF7
全名	Rho guanine nucleotide exchange factor (GEF) 7
背景介绍	Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
生物功能	Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. [UniProt]
预测分子量	90 kDa
翻译后修饰	Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.

检测图片 (1) Click the Picture to Zoom In