ARG44778
anti-ARHGAP45 antibody
anti-ARHGAP45 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes ARHGAP45 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | ARHGAP45 |
| 抗原物种 | Human |
| 抗原表位 | VDVLLQRCEG GVDAALLYAK NMAKYMKDLI SYLEKRTTLE MEFAKGLQKI AHNCRQSVMQ EPHMPLLSIY SLALEQDLEF GHSMVQAVGT LQTQTFMQPL TLRRLEHEKR RKEIKEAWHR AQRKLQEAES NLRKAKQGYV QRCEDHDKAR FLVAKAEEEQ AGSAPGAGST ATKTLDKRRR LEEEAKNKAE EAMATYRTCV ADAKTQKQEL EDTKVTALRQ IQEVIRQSDQ TIKSATISYY QMMHMQTAPL PVHFQMLCES |
| 偶联标记 | Un-conjugated |
| 別名 | ARHGAP45; Rho GTPase Activating Protein 45; KIAA0223; HMHA1; HA-1; Rho GTPase-Activating Protein 45; Histocompatibility (Minor) HA-1; Minor Histocompatibility Antigen HA-1; Minor Histocompatibility Protein HA-1; HLA-HA1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q92619 Human Minor histocompatibility protein HA-1 |
|---|---|
| 基因名称 | ARHGAP45 |
| 全名 | Rho GTPase Activating Protein 45 |
| 背景介绍 | Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. [Uniprot] |
| 细胞定位 | Cell membrane, Cell projection, Cytoplasm, Membrane. [Uniprot] |
| 翻译后修饰 | Phosphoprotein. [Uniprot] |
检测图片 (2) Click the Picture to Zoom In
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ARG44778 anti-ARHGAP45 antibody IHC-P image
Immunohistochemistry: Human tonsil stained with ARG44778 anti-ARHGAP45 antibody at 10 µg/mL dilution.
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ARG44778 anti-ARHGAP45 antibody WB image
Western blot: Raji stained with ARG44778 anti-ARHGAP45 antibody at 1 µg/mL dilution.
