ARG42676
anti-APLP2 antibody
anti-APLP2 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes APLP2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | APLP2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 340-450 of Human APLP2 (NP_001135750.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Amyloid-like protein 2; APPL2; APLP-2; CDEI box-binding protein; APPH; CDEBP; Amyloid protein homolog |
应用说明
| 预测反应性说明 | Human | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | APLP2 |
| 全名 | amyloid beta (A4) precursor-like protein 2 |
| 背景介绍 | This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| 生物功能 | May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Nucleus. [UniProt] |
| 预测分子量 | 87 kDa |
| 翻译后修饰 | The BPTI/Kunitz inhibitor domain is O-glycosylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG42676 anti-APLP2 antibody ICC/IF image
Immunofluorescence: L929 cells stained with ARG42676 anti-APLP2 antibody at 1:100 dilution.
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ARG42676 anti-APLP2 antibody WB image
Western blot: 25 µg of Rat brain lysate stained with ARG42676 anti-APLP2 antibody at 1:1000 dilution.
