ARG46009
anti-APH1A antibody
anti-APH1A antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes APH1A |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | APH1A |
| 抗原物种 | Human |
| 抗原 | A 18 amino acid synthetic peptide within aa. 80 - 130 of human APH1A. |
| 偶联标记 | Un-conjugated |
| 別名 | APH1A; APH-1A; APH-1a; 6530402N02Rik; APH-1; CGI-78; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; Aph-1alpha |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 28 kDa |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | APH1A |
| 全名 | Aph-1 Homolog A, Gamma-Secretase Subunit |
| 背景介绍 | This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011] |
| 预测分子量 | 29 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG46009 anti-APH1A antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG46009 anti-APH1A antibody.
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ARG46009 anti-APH1A antibody WB image
Western blot: RAW264.7 stained with ARG46009 anti-APH1A antibody.
