ARG46007
anti-APC2 antibody
anti-APC2 antibody for Western blot,ICC/IF and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes APC2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | APC2 |
| 抗原物种 | Human |
| 抗原 | A 18 amino acid synthetic peptide within aa. 240 - 290 of human APC2. |
| 偶联标记 | Un-conjugated |
| 別名 | adenomatosis polyposis coli 2; APC2; APCL; APCL; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -57°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95996 Human Adenomatous polyposis coli protein 2 |
|---|---|
| 基因名称 | APC2 |
| 全名 | adenomatosis polyposis coli 2 |
| 背景介绍 | This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017] |
| 生物功能 | Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). [UniProt] |
| 细胞定位 | Cytoplasm; Cytoskeleton; Golgi apparatus. [UniProt] |
| 预测分子量 | 244 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
