ARG64035
anti-APBB1 / FE65 antibody
anti-APBB1 / FE65 antibody for Western blot and Mouse
Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes APBB1 / FE65 |
|---|---|
| 反应物种 | Ms |
| 预测物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody is expected to recognise both reported isoforms (NP_001155.1 and NP_663722.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | APBB1 / FE65 |
| 抗原物种 | Human |
| 抗原 | C-GSLKPKRLGAHTP |
| 偶联标记 | Un-conjugated |
| 別名 | FE65; Amyloid beta A4 precursor protein-binding family B member 1; Protein Fe65; RIR; MGC:9072 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9QXJ1 Mouse Amyloid beta A4 precursor protein-binding family B member 1 |
|---|---|
| 背景介绍 | The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012] |
| 研究领域 | Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 77 kDa |
| 翻译后修饰 | Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-547 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1. |
检测图片 (1) Click the Picture to Zoom In
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ARG64035 anti-APBB1 / FE65 antibody WB image
Western Blot: NIH/3T3 lysate (35 µg protein in RIPA buffer) stained with ARG64035 anti-APBB1 / FE65 antibody at 0.1 µg/ml dilution.
