ARG59798
anti-AP3B1 / HPS2 antibody
anti-AP3B1 / HPS2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes AP3B1 / HPS2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AP3B1 / HPS2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 895-1094 of Human AP3B1 (NP_003655.3). |
| 偶联标记 | Un-conjugated |
| 別名 | Adaptor-related protein complex 3 subunit beta-1; AP-3 complex subunit beta-1; HPS; ADTB3A; Clathrin assembly protein complex 3 beta-1 large chain; Adaptor protein complex AP-3 subunit beta-1; ADTB3; HPS2; PE; Beta-3A-adaptin |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse liver and SW620 | ||||||
| 实际分子量 | 132 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | AP3B1 |
| 全名 | adaptor-related protein complex 3, beta 1 subunit |
| 背景介绍 | This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012] |
| 生物功能 | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [UniProt] |
| 细胞定位 | Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. [UniProt] |
| 预测分子量 | 121 kDa |
| 翻译后修饰 | Phosphorylated on serine residues. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG59798 anti-AP3B1 / HPS2 antibody WB image
Western blot: 25 µg of Mouse liver and SW620 cell lysates stained with ARG59798 anti-AP3B1 / HPS2 antibody at 1:1000 dilution.
