ARG43619
anti-AP2 alpha antibody
anti-AP2 alpha antibody for Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes AP2 alpha |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AP2 alpha |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment corresponding to a.a. M1-G166 of Human AP2 alpha (TFAP2A). |
| 偶联标记 | Un-conjugated |
| Protein Full name | Transcription factor AP-2-alpha |
| 別名 | BOFS; TFAP2; Activating enhancer-binding protein 2-alpha; AP2-alpha; Transcription factor AP-2-alpha; AP-2; AP-2alpha; AP-2 transcription factor; Activator protein 2; AP2TF |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | ~45-50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFAP2A |
| 全名 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| 背景介绍 | The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |
| 生物功能 | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. [UniProt] |
| 细胞定位 | Nucleus. |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | Sumoylated on Lys-10; which inhibits transcriptional activity. |
检测图片 (1) Click the Picture to Zoom In
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ARG43619 anti-AP2 alpha antibody WB image
Western blot: Rat spleen stained with ARG43619 anti-AP2 alpha antibody 1:5000 dilution.
