ARG45998
anti-ANKLE2 antibody
anti-ANKLE2 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Chicken Polyclonal antibody recognizes ANKLE2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Chicken |
| 克隆 | Polyclonal |
| 同位型 | IgY |
| 靶点名称 | ANKLE2 |
| 抗原物种 | Human |
| 抗原 | A 19 amino acid synthetic peptide within aa. 280 - 330 of human ANKLE2. |
| 偶联标记 | Un-conjugated |
| 別名 | ankyrin repeat and LEM domain containing 2; ANKLE2; Lem4; LEMD7; KIAA0692; LEM4; Ankyrin repeat and LEM domain-containing protein 2; LEM domain-containing protein 4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 121 kDa |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -48°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ANKLE2 |
| 全名 | ankyrin repeat and LEM domain containing 2 |
| 背景介绍 | This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014] |
| 生物功能 | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane. [UniProt] |
| 预测分子量 | 121,139,145 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
