ARG44342
anti-ANKH antibody
anti-ANKH antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ANKH |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ANKH |
| 抗原物种 | Human |
| 抗原 | Human ANKH recombinant fusion protein (a.a. sequence: 210-320). |
| 偶联标记 | Un-conjugated |
| 別名 | ANKH; ANKH Inorganic Pyrophosphate Transport Regulator; ANK; SLC62A1; CPPDD; HANK; Progressive Ankylosis Protein Homolog; Mineralization Regulator ANKH; ATP Carrier Protein ANKH; CCAL2; CMDJ; Craniometaphyseal Dysplasia, Jackson Type (Dominant); Ankylosis, Progressive (Mouse) Homolog; Ankylosis, Progressive Homolog (Mouse); Ankylosis, Progressive Homolog; KIAA1581; MANK |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.02% sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9HCJ1 Human Progressive ankylosis protein homolog |
|---|---|
| 基因名称 | ANKH |
| 全名 | ANKH Inorganic Pyrophosphate Transport Regulator |
| 背景介绍 | This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. |
| 生物功能 | Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. |
| 细胞定位 | Cell membrane, Membrane |
| 预测分子量 | 54 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG44342 anti-ANKH antibody WB image
Western blot: SH-SY5Y and OVCAR-3 stained with ARG44342 anti-ANKH antibody at 1:1000 dilution.
