ARG24152
anti-ANK1 / Ankyrin R antibody [S388A-10]
anti-ANK1 / Ankyrin R antibody [S388A-10] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [S388A-10] recognizes ANK1 / Ankyrin R |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S388A-10 |
| 同位型 | IgG2b |
| 靶点名称 | ANK1 / Ankyrin R |
| 抗原物种 | Human |
| 抗原 | Fusion protein of Human ANK1 / Ankyrin R |
| 偶联标记 | Un-conjugated |
| Protein Full name | Ankyrin-1 |
| 別名 | ANK1; Ankyrin 1; SPH1; ANK; Ankyrin 1, Erythrocytic ; Erythrocyte Ankyrin; Ankyrin-1; Ankyrin-R; ANK-1; SPH2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ANK1 |
| 全名 | Ankyrin 1 |
| 背景介绍 | Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. |
| 生物功能 | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. |
| 细胞定位 | Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulum |
| 预测分子量 | 206 kDa |
| 翻译后修饰 | Hydroxylation, Lipoprotein, Phosphoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG24152 anti-ANK1 / Ankyrin R antibody [S388A-10] ICC/IF image
Immunofluorescence: SH-SY5Y stained with ARG24152 anti-ANK1 / Ankyrin R antibody [S388A-10] at 1:100 dilution.
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ARG24152 anti-ANK1 / Ankyrin R antibody [S388A-10] WB image
Western blot: Rat Brain stained with ARG24152 anti-ANK1 / Ankyrin R antibody [S388A-10] at 1:1000 dilution.
