ARG42981
anti-ALKBH4 antibody
anti-ALKBH4 antibody for Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ALKBH4 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ALKBH4 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human ALKBH4. |
| 偶联标记 | Un-conjugated |
| 別名 | ABH4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Alkylated DNA repair protein alkB homolog 4; EC 1.14.11.- |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | K562 | ||||||
| 实际分子量 | ~ 34 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9NXW9 Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 |
|---|---|
| 基因名称 | ALKBH4 |
| 全名 | alkB homolog 4, lysine demthylase |
| 生物功能 | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Midbody. Note=Associates with the contractile ring and midbody. [UniProt] |
| 预测分子量 | 34 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42981 anti-ALKBH4 antibody WB image
Western blot: K562 cell lysate stained with ARG42981 anti-ALKBH4 antibody at 1:1000 dilution.
