ARG57176
anti-ALDH2 antibody [2C10]
anti-ALDH2 antibody [2C10] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [2C10] recognizes ALDH2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 2C10 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | ALDH2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 18-517 of Human ALDH2 |
| 偶联标记 | Un-conjugated |
| 別名 | EC 1.2.1.3; ALDH class 2; ALDM; ALDHI; Aldehyde dehydrogenase, mitochondrial; ALDH-E2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P05091 Human Aldehyde dehydrogenase, mitochondrial |
|---|---|
| 基因名称 | ALDH2 |
| 全名 | aldehyde dehydrogenase 2 family (mitochondrial) |
| 背景介绍 | This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011] |
| 预测分子量 | 56 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG57176 anti-ALDH2 antibody [2C10] WB image
Western blot: 40 µg of 1) HepG2, 2) Mouse liver, and 3) Mouse lung lysates stained with ARG57176 anti-ALDH2 antibody [2C10] at 1:1000.
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ARG57176 anti-ALDH2 antibody [2C10] WB image
Western blot: 40 µg of 1) 293T, and 2) ALDH2 transfected 293T cell lysate stained with ARG57176 anti-ALDH2 antibody [2C10] at 1:500.
