ARG40837
anti-AKR1C1 + AKR1C2 antibody
anti-AKR1C1 + AKR1C2 antibody for Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes AKR1C1 + AKR1C2 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | WB |
| 特异性 | This antibody might also react to AKR1C3 and AKR1C4 based on sequence homology analysis (> 80%). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AKR1C1 + AKR1C2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to M1-K123 of Human AKR1C1/C2. |
| 偶联标记 | Un-conjugated |
| 別名 | Chlordecone reductase homolog HAKRD; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; MCDR2; DD; SRXY8; DD/BABP; Dihydrodiol dehydrogenase 2; EC 1.-.-.-; DD2; HBAB; Dihydrodiol dehydrogenase/bile acid-binding protein; Aldo-keto reductase family 1 member C2; 3-alpha-HSD3; DDH2; EC 1.3.1.20; EC 1.1.1.357; BABP; Type III 3-alpha-hydroxysteroid dehydrogenase; AKR1C-pseudo; DD-2; TDD; HAKRD |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P52895 Human Aldo-keto reductase family 1 member C2 Swiss-port # Q6AYQ2 Rat Aldo-keto reductase family 1 member C21 |
|---|---|
| 基因名称 | AKR1C2 |
| 全名 | aldo-keto reductase family 1, member C2 |
| 背景介绍 | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| 生物功能 | Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 37 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG40837 anti-AKR1C1 + AKR1C2 antibody WB image
Western blot: Rat liver and HeLa whole cell lysates stained with ARG40837 anti-AKR1C1 + AKR1C2 antibody at 0.5 µg/ml dilution.
