ARG41262
anti-AKAP5 antibody
anti-AKAP5 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes AKAP5 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Hrs, Pig, Yeast |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AKAP5 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the middle region of Human AKAP5. (within the following region: KQFLISAENEQVGVFANDNGFEDRTSEQYETLLIETASSLVKNAIQLSIE) |
| 偶联标记 | Un-conjugated |
| 別名 | AKAP75; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; AKAP-5; H21; AKAP79; AKAP 79; A-kinase anchor protein 79 kDa; A-kinase anchor protein 5 |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Cow: 86%; Dog: 86%; Horse: 86%; Mouse: 79%; Pig: 86%; Rat: 79%; Yeast: 82% | ||||
|---|---|---|---|---|---|
| 应用建议 |
|
||||
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human muscle | ||||
| 实际分子量 | 47 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | AKAP5 |
| 全名 | A kinase (PRKA) anchor protein 5 |
| 背景介绍 | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008] |
| 生物功能 | May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. [UniProt] |
| 细胞定位 | Membrane; Lipid-anchor. Note=Associates with lipid rafts. [UniProt] |
| 预测分子量 | 47 kDa |
| 翻译后修饰 | Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
-
ARG41262 anti-AKAP5 antibody WB image
Western blot: Human muscle lysate stained with ARG41262 anti-AKAP5 antibody at 0.2 - 1 µg/ml dilution.
