ARG11086
anti-AKAP12 / Gravin antibody
anti-AKAP12 / Gravin antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Rat
概述
| 产品描述 | Sheep Polyclonal antibody recognizes AKAP12 / Gravin |
|---|---|
| 反应物种 | Rat |
| 应用 | IHC-P, IP, WB |
| 宿主 | Sheep |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AKAP12 / Gravin |
| 抗原物种 | Rat |
| 抗原 | Recombinant protein corresponding to aa. 620-1596 of Rat AKAP12 / Gravin. |
| 偶联标记 | Un-conjugated |
| 別名 | SSeCKS; AKAP250; A-kinase anchor protein 250 kDa; Gravin; A-kinase anchor protein 12; Myasthenia gravis autoantigen; AKAP 250; AKAP-12 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Rat aortic smooth muscle |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Ammonium sulfate precipitation. |
| 缓冲液 | PBS and 0.08% Sodium azide. |
| 抗菌剂 | 0.08% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | AKAP12 |
| 全名 | A kinase (PRKA) anchor protein 12 |
| 背景介绍 | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| 生物功能 | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). [UniProt] |
| 细胞定位 | Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Lipid-anchor. Note=May be part of the cortical cytoskeleton. [UniProt] |
| 预测分子量 | 181 kDa (Rat) |
检测图片 (1) Click the Picture to Zoom In
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ARG11086 anti-AKAP12 / Gravin antibody WB image
Western blot: Cultured Rat aortic smooth muscle cell lysate stained with ARG11086 anti-AKAP12 / Gravin antibody.
