ARG63980

anti-AIRE antibody

anti-AIRE antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Pig

Gene Regulation antibody; Immune System antibody

概述

产品描述 Goat Polyclonal antibody recognizes AIRE
反应物种 Hu, Pig
预测物种 Cow, Rat, Dog
应用 IHC-P, WB
特异性 This antibody is expected to recognise isoform 1 (NP_000374.1) only.
宿主 Goat
克隆 Polyclonal
同位型 IgG
靶点名称 AIRE
抗原物种 Human
抗原 C-KDVDLSQPRKGRKP
偶联标记 Un-conjugated
別名 APECED; Autoimmune regulator; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; AIRE1; PGA1; APECED protein

应用说明

应用建议
应用 推荐稀释比
IHC-PAssay - dependent
WB0.5 - 1.0 µg/ml
应用说明 IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Purified from goat serum by antigen affinity chromatography.
缓冲液 Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA.
抗菌剂 0.02% Sodium azide
稳定剂 0.5% BSA
浓度 0.5 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 326 Human AIRE

Swiss-port # O43918 Human Autoimmune regulator

背景介绍 This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
研究领域 Gene Regulation antibody; Immune System antibody
预测分子量 58 kDa
翻译后修饰 Phosphorylated. Phosphorylation could trigger oligomerization.

检测图片 (1) Click the Picture to Zoom In

  • ARG63980 anti-AIRE antibody IHC-P image

    Immunohistochemistry: paraffin embedded Human Thymus. (Steamed antigen retrieval with citrate buffer pH 6) stained with ARG63980 anti-AIRE (isoform 1) antibody at 2.5 µg/ml dilution followed by AP-staining.