ARG41233
anti-AIM2 antibody
anti-AIM2 antibody for Western blot and Human
概述
产品描述 | Goat Polyclonal antibody recognizes AIM2 |
---|---|
反应物种 | Hu |
应用 | WB |
宿主 | Goat |
克隆 | Polyclonal |
同位型 | IgG |
靶点名称 | AIM2 |
抗原物种 | Human |
抗原 | Synthetic peptide around the internal region of Human AIM2. (C-DKQYKSVTKPKPLSQ) (NP_004824.1) |
偶联标记 | Un-conjugated |
別名 | PYHIN4; Interferon-inducible protein AIM2; Absent in melanoma 2 |
应用说明
应用建议 |
|
||||
---|---|---|---|---|---|
应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
||||
实际分子量 | ~ 39 kDa |
属性
形式 | Liquid |
---|---|
纯化 | Affinity purified |
缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
抗菌剂 | 0.02% Sodium azide |
稳定剂 | 0.5% BSA |
浓度 | 0.5 mg/ml |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
---|---|
基因名称 | AIM2 |
全名 | absent in melanoma 2 |
背景介绍 | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] |
生物功能 | Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. [UniProt] |
细胞定位 | Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles. [UniProt] |
预测分子量 | 39 kDa |
检测图片 (1) Click the Picture to Zoom In