概述

产品描述	Rabbit Polyclonal antibody recognizes AFF4
反应物种	Hu, Ms
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	AFF4
抗原物种	Human
抗原	Recombinant Protein of Human AFF4.
偶联标记	Un-conjugated
別名	AF4/FMR2 family member 4; Protein AF-5q31; CHOPS; MCEF; ALL1-fused gene from chromosome 5q31 protein; Major CDK9 elongation factor-associated protein; AF5Q31

应用说明

应用建议	应用 推荐稀释比 WB 1:200-1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	MCF7

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 27125 Human AFF4 GeneID: 93736 Mouse AFF4 Swiss-port # Q9ESC8 Mouse AF4/FMR2 family member 4 Swiss-port # Q9UHB7 Human AF4/FMR2 family member 4
基因名称	AFF4
全名	AF4/FMR2 family, member 4
背景介绍	The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
生物功能	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. [UniProt]
预测分子量	127 kDa

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