ARG45786
anti-ADAMTS5 antibody
anti-ADAMTS5 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ADAMTS5 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADAMTS5 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human ADAMTS5. |
| 偶联标记 | Un-conjugated |
| 別名 | ADAMTS5; ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5; ADAMTS11; ADMP-2; Aggrecanase-2; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2); A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5; ADAM-TS 11; ADAM-TS 5; ADAMTS-11; ADAM-TS5; ADAMTS-5; EC 3.4.24.14 47; EC 3.4.24.82 47; EC 3.4.24.-; EC 3.4.24 47; ADMP2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 75 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9R001 Mouse A disintegrin and metalloproteinase with thrombospondin motifs 5 Swiss-port # Q9UNA0 Human A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|---|
| 基因名称 | ADAMTS5 |
| 全名 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 |
| 背景介绍 | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
| 生物功能 | Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. [UniProt] |
| 细胞定位 | Extracellular matrix; Secreted. [UniProt] |
| 预测分子量 | 102 kDa |
| 翻译后修饰 | Cleavage on pair of basic residues; Disulfide bond; Glycoprotein; Zymogen. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45786 anti-ADAMTS5 antibody IHC-P image
Immunohistochemistry: Human placenta stained with ARG45786 anti-ADAMTS5 antibody at 2 μg/ml dilution.
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ARG45786 anti-ADAMTS5 antibody WB image
Western blot: HepG2 stained with ARG45786 anti-ADAMTS5 antibody at 0.5 μg/ml dilution.
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ARG45786 anti-ADAMTS5 antibody WB image
Western blot: Rat liver stained with ARG45786 anti-ADAMTS5 antibody at 0.5 μg/ml dilution.
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ARG45786 anti-ADAMTS5 antibody WB image
Western blot: Mouse liver stained with ARG45786 anti-ADAMTS5 antibody at 0.5 μg/ml dilution.
