ARG57963
anti-ADAMTS1 antibody
anti-ADAMTS1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ADAMTS1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADAMTS1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 718-967 of Human ADAMTS1 (NP_008919.3). |
| 偶联标记 | Un-conjugated |
| 別名 | ADAMTS-1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; METH1; EC 3.4.24.-; ADAM-TS1; C3-C5; ADAM-TS 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse liver | ||||||
| 实际分子量 | 105 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P97857 Mouse A disintegrin and metalloproteinase with thrombospondin motifs 1 Swiss-port # Q9UHI8 Human A disintegrin and metalloproteinase with thrombospondin motifs 1 |
|---|---|
| 基因名称 | ADAMTS1 |
| 全名 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| 背景介绍 | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. [UniProt] |
| 细胞定位 | Secreted, extracellular matrix, extracellular space. [UniProt] |
| 预测分子量 | 105 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG57963 anti-ADAMTS1 antibody WB image
Western blot: 25 µg of Mouse liver lysate stained with ARG57963 anti-ADAMTS1 antibody at 1:1000 dilution.
