ARG66299
anti-ADAM19 antibody
anti-ADAM19 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Goat Polyclonal antibody recognizes ADAM19 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow, Dog, Pig |
| 应用 | IHC-P, WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADAM19 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human ADAM19 (KIQCQSSEARPLESN). |
| 偶联标记 | Un-conjugated |
| 別名 | ADAM 19; FKSG34; EC 3.4.24.-; MADDAM; Disintegrin and metalloproteinase domain-containing protein 19; MLTNB; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0). WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 实际分子量 | ~ 125 kDa (glycosylated) |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9H013 Human Disintegrin and metalloproteinase domain-containing protein 19 |
|---|---|
| 基因名称 | ADAM19 |
| 全名 | ADAM metallopeptidase domain 19 |
| 背景介绍 | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013] |
| 生物功能 | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). [UniProt] |
| 预测分子量 | 105 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG66299 anti-ADAM19 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human spleen stained with ARG66299 anti-ADAM19 antibody. Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0).
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ARG66299 anti-ADAM19 antibody WB image
Western blot: 35 µg of Human spleen lysate stained with ARG66299 anti-ADAM19 antibody at 0.1 µg/ml dilution (1 hour incubation).
