ARG23353
anti-ADAM10 / KUZ / MADM antibody [11G2] (azide free)
anti-ADAM10 / KUZ / MADM antibody [11G2] (azide free) for Flow cytometry,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Azide free Mouse Monoclonal antibody [11G2] recognizes ADAM10 / KUZ / MADM |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IP, WB |
| 特异性 | This antibody recognizes the ADAM-10 protein, either the 70 kDa form or the 97 kDa precursor form. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 11G2 |
| 同位型 | IgG1 |
| 靶点名称 | ADAM10 / KUZ / MADM |
| 抗原物种 | Human |
| 抗原 | Jurkat cell line |
| 偶联标记 | Un-conjugated |
| 別名 | Kuzbanian protein homolog; kuz; HsT18717; MADM; RAK; EC 3.4.24.81; ADAM 10; AD18; CDw156; Mammalian disintegrin-metalloprotease; CD antigen CD156c; AD10; Disintegrin and metalloproteinase domain-containing protein 10; CD156c |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | Sterile-filtered through 0.22 µm. |
| 缓冲液 | PBS |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14672 Human Disintegrin and metalloproteinase domain-containing protein 10 |
|---|---|
| 基因名称 | ADAM10 |
| 全名 | ADAM metallopeptidase domain 10 |
| 背景介绍 | Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. [UniProt] |
| 预测分子量 | 84 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. [UniProt] |
