ARG43380
anti-ACVR1C / ALK7 antibody
anti-ACVR1C / ALK7 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ACVR1C / ALK7 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ACVR1C / ALK7 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 22-113 of Human ACVR1C / ALK7 (NP_660302.2). |
| 偶联标记 | Un-conjugated |
| 別名 | ALK7; EC 2.7.11.30; Activin receptor-like kinase 7; Activin receptor type IC; ACVRLK7; ALK-7; ACTR-IC; Activin receptor type-1C |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SH-SY5Y | ||||||
| 实际分子量 | ~ 60 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ACVR1C |
| 全名 | activin A receptor, type IC |
| 背景介绍 | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] |
| 生物功能 | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 55 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG43380 anti-ACVR1C / ALK7 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse stomach tissue stained with ARG43380 anti-ACVR1C / ALK7 antibody at 1:100 dilution.
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ARG43380 anti-ACVR1C / ALK7 antibody WB image
Western blot: 25 µg of SH-SY5Y cell lysate stained with ARG43380 anti-ACVR1C / ALK7 antibody at 1:1000 dilution.
