概述

产品描述	Rabbit Polyclonal antibody recognizes ACSL5
反应物种	Hu, Ms, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	ACSL5
抗原物种	Human
抗原	Recombinant protein of Human ACSL5
偶联标记	Un-conjugated
別名	FACL5; ACS5; Long-chain-fatty-acid--CoA ligase 5; ACS2; Long-chain acyl-CoA synthetase 5; EC 6.2.1.3; LACS 5

应用说明

预测反应性说明	Human, Rat
应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse brain

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 433256 Mouse ACSL5 GeneID: 51703 Human ACSL5 GeneID: 94340 Rat ACSL5 Swiss-port # O88813 Rat Long-chain-fatty-acid--CoA ligase 5 Swiss-port # Q8JZR0 Mouse Long-chain-fatty-acid--CoA ligase 5 Swiss-port # Q9ULC5 Human Long-chain-fatty-acid--CoA ligase 5 More
基因名称	ACSL5
全名	acyl-CoA synthetase long-chain family member 5
背景介绍	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能	Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. [UniProt]
研究领域	Metabolism antibody; Signaling Transduction antibody
预测分子量	76 kDa

检测图片 (1) Click the Picture to Zoom In