ARG59829
anti-ACOT8 antibody
anti-ACOT8 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ACOT8 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ACOT8 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-220 of Human ACOT8 (NP_005460.2). |
| 偶联标记 | Un-conjugated |
| 別名 | hACTE-III; hTE; Choloyl-coenzyme A thioesterase; EC 3.1.2.27; Peroxisomal acyl-coenzyme A thioester hydrolase 1; HNAACTE; PTE1; PTE2; Peroxisomal long-chain acyl-CoA thioesterase 1; PTE-2; PTE-1; Thioesterase II; hACTEIII; HIV-Nef-associated acyl-CoA thioesterase; Acyl-CoA thioesterase 8; Acyl-coenzyme A thioesterase 8 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa and Jurkat | ||||
| 实际分子量 | 36 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ACOT8 |
| 全名 | acyl-CoA thioesterase 8 |
| 背景介绍 | The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010] |
| 生物功能 | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. [UniProt] |
| 细胞定位 | Cytoplasm. Peroxisome matrix. Note=Predominantly localized in the peroxisome (PubMed:10092594, PubMed:15194431). [UniProt] |
| 预测分子量 | 36 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG59829 anti-ACOT8 antibody WB image
Western blot: 25 µg of HeLa and Jurkat cell lysates stained with ARG59829 anti-ACOT8 antibody at 1:3000 dilution.
