ARG57957
anti-ACMSD antibody
anti-ACMSD antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ACMSD |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ACMSD |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-336 of Human ACMSD (NP_612199.2). |
| 偶联标记 | Un-conjugated |
| 別名 | EC 4.1.1.45; Picolinate carboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse kidney | ||||
| 实际分子量 | 38 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8R519 Mouse 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Swiss-port # Q8R5M5 Rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
|---|---|
| 基因名称 | ACMSD |
| 全名 | aminocarboxymuconate semialdehyde decarboxylase |
| 背景介绍 | The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004] |
| 生物功能 | Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. [UniProt] |
| 预测分子量 | 38 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG57957 anti-ACMSD antibody WB image
Western blot: 25 µg of Mouse kidney lysate stained with ARG57957 anti-ACMSD antibody at 1:1000 dilution.
