anti-ACER2 antibody

anti-ACER2 antibody for Western blot and Human,Rat

publication_link 参考文献1


产品描述 Rabbit Polyclonal antibody recognizes ACER2
反应物种 Hu, Rat
预测物种 Ms, Mk
应用 WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 ACER2
抗原物种 Human
抗原 KLH-conjugated synthetic peptide within the center region of Human ACER2.
偶联标记 Un-conjugated
別名 AlkCDase 2; Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like; EC; ASAH3L; ALKCDase2; Alkaline ceramidase 2; Alkaline CDase 2; haCER2


应用 推荐稀释比
WB1:500 - 1:1000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量 ~ 32 kDa


形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol.
抗菌剂 0.01% Sodium azide
稳定剂 30% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 340485 Human ACER2

Swiss-port # Q5QJU3 Human Alkaline ceramidase 2

基因名称 ACER2
全名 alkaline ceramidase 2
背景介绍 The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]). [supplied by OMIM, Jul 2010]
生物功能 Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876). [UniProt]
细胞定位 Golgi apparatus membrane; Multi-pass membrane protein. [UniProt]
预测分子量 31 kDa

检测图片 (1) Click the Picture to Zoom In

  • ARG66642 anti-ACER2 antibody WB image

    Western blot: MCF7 and PC12 whole cell lysates stained with ARG66642 anti-ACER2 antibody.


TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.

WB / Human

Shan Zhang et al.
Cell Death Dis.,  (2020)