anti-ACE2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Rabbit Polyclonal antibody recognizes ACE2
|应用||ICC/IF, IHC-P, WB|
|特异性||This antibody has no cross response to ACE1.|
|抗原||Synthetic peptide within aa. 180-230 of Human ACE2.|
|別名||Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme 2; Metalloprotease MPROT15; ACE-related carboxypeptidase; EC 220.127.116.11|
|应用说明||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|阳性对照||Human Kidney Tissue Lysate|
|实际分子量||~ 105 kDa|
|纯化||Affinity purification with immunogen.|
|缓冲液||PBS and 0.02% Sodium azide|
|抗菌剂||0.02% Sodium azide|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|全名||angiotensin I converting enzyme 2|
|背景介绍||The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]|
|生物功能||Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. [UniProt]|
ACE2 antibodies; ACE2 ELISA Kits; ACE2 recombinant proteins; Anti-Rabbit IgG secondary antibodies;
HMGB1, a biomarker and therapeutic target in COVID-19
ACE2, receptor of 2019-nCoV
|翻译后修饰||N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.
检测图片 (3) Click the Picture to Zoom In
ARG55800 anti-ACE2 antibody WB image
Western blot: Human kidney lysate stained with ARG55800 anti-ACE2 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml dilution.
ARG55800 anti-ACE2 antibody IHC-P image
Immunohistochemistry: paraffin-embedded Human kidney tissue stained with ARG55800 anti-ACE2 antibody at 2 µg/ml dilution.
ARG55800 anti-ACE2 antibody ICC/IF image
Immunofluorescence: Human Kidney cells stained with ARG55800 anti-ACE2 antibody at 20 µg/ml dilution.