ARG55800

anti-ACE2 antibody

anti-ACE2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

概述

产品描述

Rabbit Polyclonal antibody recognizes ACE2

反应物种 Hu
预测物种 Ms
应用 ICC/IF, IHC-P, WB
特异性 This antibody has no cross response to ACE1.
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 ACE2
抗原物种 Human
抗原 Synthetic peptide within aa. 180-230 of Human ACE2.
偶联标记 Un-conjugated
別名 Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme 2; Metalloprotease MPROT15; ACE-related carboxypeptidase; EC 3.4.17.23

应用说明

应用建议
应用 推荐稀释比
ICC/IF20 µg/ml
IHC-P2 µg/ml
WB2 µg/ml
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human Kidney Tissue Lysate
实际分子量 ~ 105 kDa

属性

形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 PBS and 0.02% Sodium azide
抗菌剂 0.02% Sodium azide
浓度 1 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 59272 Human ACE2

Swiss-port # Q9BYF1 Human Angiotensin-converting enzyme 2

基因名称 ACE2
全名 angiotensin I converting enzyme 2
背景介绍 The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
生物功能 Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. [UniProt]
产品亮点 Related products:
ACE2 antibodies; ACE2 ELISA Kits; ACE2 recombinant proteins; Anti-Rabbit IgG secondary antibodies;
Related news:
HMGB1, a biomarker and therapeutic target in COVID-19
ACE2, receptor of 2019-nCoV
预测分子量 92 kDa
翻译后修饰 N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.

检测图片 (3) Click the Picture to Zoom In

  • ARG55800 anti-ACE2 antibody WB image

    Western blot: Human kidney lysate stained with ARG55800 anti-ACE2 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml dilution.

  • ARG55800 anti-ACE2 antibody IHC-P image

    Immunohistochemistry: paraffin-embedded Human kidney tissue stained with ARG55800 anti-ACE2 antibody at 2 µg/ml dilution.

  • ARG55800 anti-ACE2 antibody ICC/IF image

    Immunofluorescence: Human Kidney cells stained with ARG55800 anti-ACE2 antibody at 20 µg/ml dilution.