概述

产品描述	Mouse Monoclonal antibody recognizes ACE2
反应物种	Hu
应用	WB
宿主	Mouse
克隆	Monoclonal
克隆号	881CT16.4.4
同位型	IgM, kappa
靶点名称	ACE2
抗原	Purified His-tagged ACE2 protein.
偶联标记	Un-conjugated
別名	Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme 2; Metalloprotease MPROT15; ACE-related carboxypeptidase; EC 3.4.17.23

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	MCF7
实际分子量	~ 105 kDa

属性

形式	Liquid
纯化	Purification by euglobulin precipitation.
缓冲液	PBS and 0.09% (W/V) Sodium azide
抗菌剂	0.09% (W/V) Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 59272 Human ACE2 Swiss-port # Q9BYF1 Human Angiotensin-converting enzyme 2
基因名称	ACE2
全名	angiotensin I converting enzyme 2
背景介绍	The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
生物功能	Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. [UniProt]
细胞定位	Processed angiotensin-converting enzyme 2: Secreted
产品亮点	Related products: ACE2 antibodies; ACE2 ELISA Kits; ACE2 recombinant proteins; Anti-Mouse IgM secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 ACE2, receptor of 2019-nCoV
研究领域	Cell Biology and Cellular Response antibody
预测分子量	92 kDa
翻译后修饰	N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.

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