概述

产品描述	Rabbit Polyclonal antibody recognizes ABCG2
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	ABCG2
抗原物种	Human
抗原	Synthetic peptide derived from Human ABCG2.
偶联标记	Un-conjugated
別名	BCRP1; Urate exporter; BCRP; MRX; Placenta-specific ATP-binding cassette transporter; EST157481; GOUT1; MXR; Mitoxantrone resistance-associated protein; CDw338; CD338; ATP-binding cassette sub-family G member 2; ABC15; ABCP; UAQTL1; Breast cancer resistance protein; MXR1; MXR-1; BMDP; CD antigen CD338

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 9429 Human ABCG2 Swiss-port # Q9UNQ0 Human ATP-binding cassette sub-family G member 2
基因名称	ABCG2
全名	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
背景介绍	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
生物功能	High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. [UniProt]
细胞定位	Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. [UniProt]
预测分子量	72 kDa
翻译后修饰	Glycosylation-deficient ABCG2 is normally expressed and functional. [UniProt]

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