ARG10603
anti-ABCC1 / MRP1 antibody
anti-ABCC1 / MRP1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ABCC1 / MRP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ABCC1 / MRP1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide from Human MRP1 protein. (LLQQRGLFYSMAKDAGLV) |
| 偶联标记 | Un-conjugated |
| 別名 | GS-X; ATP-binding cassette sub-family C member 1; ABCC; Leukotriene C; ABC29; MRP; 4; LTC4 transporter; MRP1; Multidrug resistance-associated protein 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.025% Sodium azide and 2.5% BSA |
| 抗菌剂 | 0.025% Sodium azide |
| 稳定剂 | 2.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O35379 Mouse Multidrug resistance-associated protein 1 Swiss-port # P33527 Human Multidrug resistance-associated protein 1 |
|---|---|
| 基因名称 | ABCC1 |
| 全名 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
| 背景介绍 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] |
| 生物功能 | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. [UniProt] |
| 细胞定位 | Cell membrane |
| 预测分子量 | 172 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG10603 anti-ABCC1 / MRP1 antibody WB image
Western blot: 1) Jurkat, 2) CEM, and 3) A549 cell lysates stained with ARG10603 anti-ABCC1 / MRP1 antibody.
