ARG45135
anti-67 kDa Laminin Receptor antibody
anti-67 kDa Laminin Receptor antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes 67 kDa Laminin Receptor |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | 67 kDa Laminin Receptor |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human 67 kDa Laminin Receptor. |
| 偶联标记 | Un-conjugated |
| 別名 | RPSA; ribosomal protein SA; RPSA; Colon carcinoma laminin-binding protein; 67LR; lamR; 37LRP; 37/67 kDa laminin receptor; p40; LBP; LRP; Laminin-binding protein precursor p40; LamR; 40S ribosomal protein SA; Laminin receptor 1; LRP/LR; ICAS; LAMR1; LBP/p40; NEM/1CHD4; 37 kDa laminin receptor precursor; 67 kDa laminin receptor; Multidrug resistance-associated protein MGr1-Ag; SA; LAMBR |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | 40 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RPSA |
| 全名 | ribosomal protein SA |
| 背景介绍 | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. [UniProt] |
| 细胞定位 | Cell membrane; Cytoplasm; Nucleus. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Acetylation; Isopeptide bond; Phosphoprotein; Ubl conjugation . [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45135 anti-67 kDa Laminin Receptor antibody IHC-P image
Immunohistochemistry: Human mammary cancer stained with ARG45135 anti-67 kDa Laminin Receptor antibody at 1 μg/ml dilution.
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ARG45135 anti-67 kDa Laminin Receptor antibody ICC/IF image
Immunofluorescence: U20S stained with ARG45135 anti-67 kDa Laminin Receptor antibody at 2 ug/ml dilution.
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ARG45135 anti-67 kDa Laminin Receptor antibody WB image
Western blot: Hela and U2OS stained with ARG45135 anti-67 kDa Laminin Receptor antibody at 0.5 μg/ml dilution.
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ARG45135 anti-67 kDa Laminin Receptor antibody FACS image
Flow Cytometry: A431 stained with ARG45135 anti-67 kDa Laminin Receptor antibody at 1 µg/10^6 cells dilution.
