ARG83761
Rat IL4 ELISA Kit
Rat IL4 ELISA 试剂盒 for ELISA and Rat
概述
| 产品描述 | ARG83761 Rat IL4 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Rat IL4 in serum, plasma and cell culture supernatants. |
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| 反应物种 | Rat |
| 应用 | ELISA |
| 靶点名称 | IL4 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 15.63 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 31.25 - 2000 pg/ml |
| 样本量 | 50 µl |
| 精确 | Intra-Assay CV: <10% Inter-Assay CV: <10% |
| 別名 | IL4; Interleukin 4; IL-4; Lymphocyte Stimulatory Factor 1; BCGF-1; BCGF1; BSF1; B_cell Stimulatory Factor 1; B Cell Growth Factor 1; Interleukin-4; Binetrakin; Pitrakinra; MGC79402; BSF-1; B-Cell Stimulatory Factor 1 |
应用说明
| 检测时间 | 4 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 4°C, -20°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL4 |
| 全名 | Interleukin 4 |
| 背景介绍 | The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020] |
| 生物功能 | Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6. [UniProt] |
| 翻译后修饰 | Disulfide bond, Glycoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG83761 Rat IL4 ELISA Kit standard curve image
ARG83761 Rat IL4 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83761 Rat IL4 ELISA Kit User manual |
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