ARG83503
Rat Haptoglobin ELISA Kit
Rat Haptoglobin ELISA 试剂盒 for ELISA and Rat
Cell Biology and Cellular Response antibody
概述
| 产品描述 | ARG83503 Rat Haptoglobin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Rat Haptoglobin in Plasma, Serum and Urine |
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| 反应物种 | Rat |
| 应用 | ELISA |
| 靶点名称 | Haptoglobin |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 0.975 ng/ml |
| 样品类型 | Plasma, Serum and Urine |
| 标准范围 | 1.95 - 125 ng/ml |
| 样本量 | 100 μl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | HPA1S; Haptoglobin; BP; HP2ALPHA2; Zonulin |
应用说明
| 检测时间 | 1 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HP |
| 全名 | haptoglobin |
| 背景介绍 | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |
| 生物功能 | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody |
| Title | Download Link |
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| ARG83503 Rat Haptoglobin ELISA Kit User manual |
 Download
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