ARG70204

Pig IL4 recombinant protein (Active) (His-tagged, C-ter)

Pig IL4 recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE

概述

产品描述 E. coli expressed, His-tagged (C-ter) Active Pig IL4 recombinant protein
应用 SDS-PAGE
靶点名称 IL4
物种 Pig
A.A. 序列 His25 - Cys133
表达系统 E. coli
生物活性 Active
活性说明 Determined by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is <0.6 ng/mL.
別名 BSF-1; IL-4; B-cell stimulatory factor 1; BCGF1; Lymphocyte stimulatory factor 1; BCGF-1; Interleukin-4; Pitrakinra; Binetrakin; BSF1

属性

形式 Powder
纯化说明 Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test.
纯度 >98% (by SDS-PAGE)
缓冲液 PBS (pH 7.4)
复溶 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
存放说明 For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

基因名称 IL4
全名 interleukin 4
背景介绍 The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
生物功能 Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. [UniProt]
细胞定位 Secreted. [UniProt]

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  • ARG70204 Pig IL4 recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image

    SDS-PAGE analysis of ARG70204 Pig IL4 recombinant protein (Active) (His-tagged, C-ter).