Phospho p53 Antibody Duo (Total, pS15)
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody
|ARG20150||anti-p53 phospho (Ser15) antibody||Rabbit pAb||Hu, Ms, Rat||IHC, IP, WB||25 μg|
|ARG51081||anti-p53 antibody||Rabbit pAb||Hu||WB, IHC-P, ICC/IF||50 μl|
|产品描述||P53, also known as tumor antigen p53, acts as a tumor suppressor in many tumor types to induce growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Upon gamma-irradiation and DNA damage, p53 is phosphorylated at Ser15 residue and this increases its ability to recruit CBP/p300 which in turns increase the overall acetylation of C-terminus of p53 protein. Acetylation of C-terminal domain can dramatically increase site-specific DNA binding ability pf p53 protein on both short oligonucleotides and long DNA fragments. Zhao et al. 2008. Cell cycle 7(19): 3048-55 Lambert et al. 1998. J Biol Chem 273(49): 33048 Luo et al. 2004. PNAS 101(8): 2259
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|別名||Phospho p53 antibody; Phospho tumor protein p53 antibody; p53 phospho (Ser15) antibody; p53 antibody|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|全名||Phospho tumor protein p53 Antibody Duo (Total, pS15)|
|研究领域||Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody|
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ARG20150 anti-P53 phospho (Ser15) antibody WB image
Western Blot: 1. Untreated HeLa cell 2. UV-traeted HeLa cell stained with anti-p53 (phospho Ser15) antibody (ARG20150).
The antibody detects ~53 kDa Ser15 phosphorylated p53. It does not react with non-phosphorylated p53 or p53 phosphorylated at other sites.
ARG51081 anti-p53 antibody WB image
Western Blot: extracts from MDA and JK cells stained with anti-p53 antibody ARG51081.
ARG51081 anti-p53 antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-p53 antibody ARG51081 (left) or the same antibody preincubated with blocking peptide (right).
ARG51081 anti-p53 antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-p53 antibody ARG51081.