ARG63053
Mouse anti-Human Lambda Light Chain antibody [4C2]
Mouse anti-Human Lambda Light Chain 抗体 [4C2] for ELISA,Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Human
Immune System antibody
概述
| 产品描述 | Mouse Monoclonal antibody [4C2] recognizes Human Lambda Light Chain |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Goat, Gpig, Hm, Rb, Sheep |
| 应用 | ELISA, FACS, IHC-Fr, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 4C2 |
| 同位型 | IgG1 |
| 靶点名称 | Lambda Light Chain |
| 抗原物种 | Human |
| 目标Ig | Human Lambda light chains |
| 偶联标记 | Un-conjugated |
| 別名 | IGL@; IGLC6 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | FACS: Ramos |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from hybridoma culture supernatant by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IGL |
| 全名 | immunoglobulin lambda locus |
| 背景介绍 | Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008] |
| 研究领域 | Immune System antibody |
检测图片 (1) Click the Picture to Zoom In
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ARG63053 Mouse anti-Human Lambda Light Chain antibody [4C2] FACS image
Flow Cytometry: Human peripheral blood stained with ARG63053 Mouse anti-Human Lambda Light Chain antibody [4C2], followed by incubation with APC-labelled Goat anti-Mouse secondary antibody.
