ARG70570
Mouse Leptin recombinant protein (Fc-tagged)
Mouse Leptin recombinant protein (Fc-tagged) for SDS-PAGE
概述
| 产品描述 | CHO expressed, Fc-tagged Mouse Leptin recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | Leptin |
| A.A. 序列 | Val22 - Cys167 |
| 表达系统 | CHO |
| 別名 | LEP; Leptin; OBS; OB; Leptin (Murine Obesity Homolog); Leptin (Obesity Homolog, Mouse); Obesity Factor; Obese Protein; Obese, Mouse, Homolog Of; LEPD |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | LEP |
|---|---|
| 全名 | Leptin |
| 背景介绍 | This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017] |
| 生物功能 | Increases CD4+CD25- T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation. [Uniprot] |
