ARG70595
Mouse CD30 recombinant protein (His-tagged, C-ter)
Mouse CD30 recombinant protein (His-tagged, C-ter) for SDS-PAGE
Cancer antibody; Immune System antibody
概述
| 产品描述 | CHO expressed, His-tagged (C-ter) Mouse CD30 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CD30 |
| 物种 | Mouse |
| A.A. 序列 | Met1 - Thr258 |
| 表达系统 | CHO |
| 別名 | TNFRSF8; tumor necrosis factor receptor superfamily, member 8; Tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30; Ki-1; Lymphocyte activation antigen CD30; CD antigen CD30; D1S166E; CD30L receptor |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is<0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TNFRSF8 |
|---|---|
| 全名 | tumor necrosis factor receptor superfamily, member 8 |
| 背景介绍 | CD30 is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | CD30 is a receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). [UniProt] |
| 细胞定位 | Cell membrane; Membrane. [UniProt] |
| 研究领域 | Cancer antibody; Immune System antibody |
| 翻译后修饰 | Phosphorylated on serine and tyrosine residues. [UniProt] |
