ARG83218
Human alpha 2 Macroglobulin ELISA Kit (Rapid One-Step)
Human alpha 2 Macroglobulin ELISA 试剂盒 (Rapid One-Step) for ELISA and Human
概述
| 产品描述 | ARG83218 Human alpha 2 Macroglobulin ELISA Kit (Rapid One-Step) is an Enzyme Immunoassay kit for the quantification of Human alpha 2 Macroglobulin in Serum, Plasma, Cell lysates and Cell culture supernatants. It is a rapid One-step 90 minutes protocol. |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | alpha 2 Macroglobulin |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 300 pg/ml |
| 检测范围 | 625 pg/ml - 40,000 pg/ml |
| 样品类型 | Serum, Plasma, Cell lysates and Cell culture supernatants |
| 精确 | Intra-Assay CV: 6.8% Inter-Assay CV: 7.3% |
| 別名 | CPAMD5; Alpha-2-macroglobulin; S863-7; FWP007; Alpha-2-M; A2MD; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 |
应用说明
| 检测时间 | ~ 1.5 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | A2M |
| 全名 | alpha-2-macroglobulin |
| 背景介绍 | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] |
| 生物功能 | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG83218 Human alpha 2 Macroglobulin ELISA Kit (Rapid One-Step) standard curve image
ARG83218 Human alpha 2 Macroglobulin ELISA Kit (Rapid One-Step) results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83218 Human alpha 2 Macroglobulin ELISA Kit (Rapid One-Step) User manual |
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