ARG70523

Human Sclerostin recombinant protein (His-tagged)

Human Sclerostin recombinant protein (His-tagged) for SDS-PAGE

概述

产品描述 CHO expressed, His-tagged Human Sclerostin recombinant protein
应用 SDS-PAGE
靶点名称 Sclerostin
A.A. 序列 Gln24 - Tyr213
表达系统 CHO
別名 SOST; Sclerostin; DAND6; VBCH; Sclerosteosis; SOST1; CDD

属性

形式 Powder
纯度 > 85% (by SDS-PAGE)
缓冲液 PBS (pH 7.4)
复溶 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
存放说明 For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

基因名称 SOST
全名 Sclerostin
背景介绍 Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
生物功能 Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. [Uniprot]