ARG83666
Human NOTCH3 ELISA Kit
Human NOTCH3 ELISA 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83666 Human NOTCH3 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human NOTCH3 in Serum, plasma (heparin, EDTA) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | NOTCH3 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 30 pg/ml |
| 样品类型 | Serum, plasma (heparin, EDTA) and cell culture supernatants. |
| 标准范围 | 46.9 - 3000 pg/ml |
| 样本量 | 100 μl |
| 精确 | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| 別名 | NOTCH3; Notch Receptor 3; Notch 3; CASIL; Neurogenic Locus Notch Homolog Protein 3; CADASIL; Notch (Drosophila) Homolog 3; Notch Homolog 3 (Drosophila); Notch Homolog 3; CADASIL1; IMF2; LMNS |
应用说明
| 检测时间 | 4 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 4°C, -20°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UM47 Human Neurogenic locus notch homolog protein 3 |
|---|---|
| 基因名称 | NOTCH3 |
| 全名 | Notch Receptor 3 |
| 背景介绍 | This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] |
| 生物功能 | Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. [UniProt] |
| 细胞定位 | Cell membrane, Membrane, Nucleus. [UniProt] |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Methylation, Phosphoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
-
ARG83666 Human NOTCH3 ELISA Kit standard curve image
ARG83666 Human NOTCH3 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
|---|---|
| ARG83666 Human NOTCH3 ELISA Kit User manual |
 Download
|
