ARG70580
Human MUC16 / CA125 recombinant protein (His-tagged, C-ter)
Human MUC16 / CA125 recombinant protein (His-tagged, C-ter) for SDS-PAGE
概述
| 产品描述 | CHO expressed, His-tagged (C-ter) Human MUC16 / CA125 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | MUC16 / CA125 |
| 物种 | Human |
| A.A. 序列 | Pro13810 - Pro14451 |
| 表达系统 | CHO |
| 別名 | MUC16; mucin 16, cell surface associated; Mucin-16; MUC-16; Ovarian carcinoma antigen CA125; CA125; Ovarian cancer-related tumor marker CA125; CA-125 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is<0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | MUC16 |
|---|---|
| 全名 | mucin 16, cell surface associated |
| 背景介绍 | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017] |
| 生物功能 | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| 细胞定位 | Cell membrane; Membrane; Secreted. [UniProt] |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
