ARG81248
Human MUC-4 ELISA Kit
Human MUC-4 ELISA 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG81248 Human MUC-4 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human MUC-4 in serum or plasma. |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | MUC4 |
| 偶联标记 | HRP |
| 偶联标记说明 | Read at 450 nm. |
| 灵敏度 | 60 pg/ml |
| 样品类型 | Serum or plasma. |
| 标准范围 | 312.5 - 20000 pg/ml |
| 样本量 | 100 µl |
| 別名 | ASGP-1; ASGP-2; HSA276359; MUC-4; Mucin-4; Pancreatic adenocarcinoma mucin; Ascites sialoglycoprotein 1; Tracheobronchial mucin; ASGP; Testis mucin; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein |
应用说明
| 检测时间 | ~ 3 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MUC4 |
| 全名 | mucin 4, cell surface associated |
| 背景介绍 | The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. [UniProt] |
| 产品亮点 | Related products: MUC4 antibodies; MUC4 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. mucrnin-4 alpha chain is highly O-glycosylated. mucin-4 beta chain is predominantly N-glycosylated. |
检测图片 (1) Click the Picture to Zoom In
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ARG81248 Human MUC-4 ELISA Kit standard curve image
ARG81248 Human MUC-4 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG81248 Human MUC-4 ELISA Kit User manual |
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