ARG83454
Human Hepcidin ELISA Kit
Human Hepcidin ELISA 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83454 Human Hepcidin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Hepcidin in Serum, plasma and cell culture supernatants., Urine |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | Hepcidin |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 4 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants., Urine |
| 标准范围 | 7.8 - 500 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | HAMP; Hepcidin Antimicrobial Peptide; LEAP1; HEPC; LEAP-1; HFE2B; Liver-Expressed Antimicrobial Peptide 1; Putative Liver Tumor Regressor; Hepcidin; PLTR; Hepcidin Preproprotein |
应用说明
| 检测时间 | 3.5 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HAMP |
| 全名 | Hepcidin Antimicrobial Peptide |
| 背景介绍 | he product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014] |
| 生物功能 | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. |
| 细胞定位 | Secreted |
| 翻译后修饰 | Cleavage on pair of basic residues, Disulfide bond |
检测图片 (1) Click the Picture to Zoom In
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ARG83454 Human Hepcidin ELISA Kit standard curve image
ARG83454 Human Hepcidin ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83454 Human Hepcidin ELISA Kit User manual |
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