ARG70556
Human Glucagon (GLP1) recombinant protein (His-tagged)
Human Glucagon (GLP1) recombinant protein (His-tagged) for SDS-PAGE
概述
| 产品描述 | CHO expressed, His-tagged Human Glucagon (GLP1) recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | Glucagon (GLP1) |
| 物种 | Human |
| A.A. 序列 | Arg21 - Lys180 |
| 表达系统 | CHO |
| 別名 | GCG; Glucagon; GLP-1; GLP1; GLP2; GRPP; Glicentin-Related Polypeptide; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Preproglucagon; Pro-Glucagon |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 90% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | GCG |
|---|---|
| 全名 | Glucagon |
| 背景介绍 | The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008] |
| 生物功能 | Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. [Uniprot] |
