ARG20576
Goat anti-Mouse IgM antibody (HRP), pre-adsorbed
Goat anti-Mouse IgM 抗体 (HRP), pre-adsorbed for ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse
Immune System antibody
概述
| 产品描述 | HRP-conjugated Goat Polyclonal antibody recognizes Mouse IgM |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| 特异性 | The antibody reacts with the heavy chain of Mouse IgM. The antibody is pre-adsorbed with Mouse IgG and IgA, so the antibody may not react with Mouse IgG and IgA, but may react with immunoglobulins from other species. |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IgM |
| 抗原物种 | Mouse |
| 抗原 | Mouse IgM |
| 目标Ig | IgM |
| 偶联标记 | HRP |
| 別名 | MU; VH; AGM1; Igm; muH; Igh6; Igh-6; Igh-M; |
应用说明
| 预吸附 | Mouse IgG and IgA. | ||||||||||||||
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| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 50% PBS (pH 7.4) and 50% Glycerol |
| 稳定剂 | 50% Glycerol |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Ighm |
| 全名 | immunoglobulin heavy constant mu |
| 背景介绍 | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010] |
| 生物功能 | IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions (By similarity). [UniProt] |
| 研究领域 | Immune System antibody |
检测图片 (1) Click the Picture to Zoom In
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ARG20576 Goat anti-Mouse IgM antibody (HRP) (pre-adsorbed) ELISA image
ELISA: The plate was coated with purified Mouse IgM, IgG, and IgA. Immunoglobulins were detected with serially diluted ARG20576 Goat anti-Mouse IgM antibody (HRP) (pre-adsorbed).
