ARG53970
anti-Tn antigen antibody [Tn 218]
anti-Tn antigen antibody [Tn 218] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Tn Antigen antibody; sTn Antigen antibody; T Antigen antibody
参考文献1
概述
| 产品描述 | Mouse Monoclonal antibody [Tn 218] recognizes Tn antigen |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | Tn 218 |
| 同位型 | IgM, kappa |
| 靶点名称 | Tn antigen |
| 抗原 | Asialo ovine submaxillary mucin (AOSM) |
| 抗原表位 | alpha GalNacOSer/Thr |
| 偶联标记 | Un-conjugated |
应用说明
| 应用建议 |
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| 应用说明 | IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears). IHC: Using streptavidin-Biotin system or polymer system for 30 minutes at RT. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Human gastrointestinal tumor. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS (pH 7.4) and 0.05% Sodium azide |
| 抗菌剂 | 0.05% Sodium azide |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 背景介绍 | Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator. |
|---|---|
| 细胞定位 | Cytoplasmic and epithelial membrane |
| 产品亮点 | Related Antibody Duos and Panels: ARG30015 Tn Antigen Antibody Duo (sTn, Tn) ARG30016 T / Tn Antigen Antibody Duo (T , Tn) Related products: Tn antigen antibodies; Tn antigen Duos / Panels; Anti-Mouse IgM secondary antibodies; |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Tn Antigen antibody; sTn Antigen antibody; T Antigen antibody |
| 预测分子量 | several HM weight glycoproteins. |
文献引用
Shigella flexneri Targets Human Colonic Goblet Cells by O Antigen Binding to Sialyl-Tn and Tn Antigens via Glycan-Glycan Interactions.
ICC/IF /
