ARG23079

anti-Thrombomodulin antibody [QBEND/40]

anti-Thrombomodulin antibody [QBEND/40] for IHC-Frozen sections,Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections and Human,Rabbit

概述

产品描述 Mouse Monoclonal antibody [QBEND/40] recognizes Thrombomodulin
Mouse anti Human CD141 antibody, clone QBEND/40 recognizes human CD141, also known as thrombomodulin. Mouse anti Human CD141 antibody, clone QBEND/40 all human endothelium tested, but does not inhibit thrombomodulin dependent activation of protein C.
反应物种 Hu, Rb
应用 FACS, IHC-Fr, IHC-P
宿主 Mouse
克隆 Monoclonal
克隆号 QBEND/40
同位型 IgG2a
靶点名称 Thrombomodulin
抗原物种 Human
抗原 Human endothelium derived thrombomodulin.
偶联标记 Un-conjugated
全名 thrombomodulin
別名 THRM; CD antigen CD141; THPH12; TM; Thrombomodulin; CD141; BDCA3; Fetomodulin; AHUS6

应用说明

应用建议
应用 推荐稀释比
FACSNeat
IHC-Fr1:10 - 1:100
IHC-P1:10 - 1:50
应用说明 IHC-P: Antigen Retrieval: Boil tissue section in Sodium citrate buffer (pH 6.0).
FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Tissue Culture Supernatant.
缓冲液 Tissue Culture Supernatant, 0.2M Tris/HCl (pH 7.4), 5-10% foetal calf serum and 0.01% Sodium azide
抗菌剂 0.01% Sodium azide
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 7056 Human THBD

Swiss-port # P07204 Human Thrombomodulin

基因名称 THBD
基因全名 thrombomodulin
背景介绍 The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
生物功能 Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [UniProt]
翻译后修饰 N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

检测图片 (8) Click the Picture to Zoom In

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human spleen cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40]. (Low power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human Tonsil cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40]. (Low power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human Tonsil cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40]. (Medium power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human Tonsil cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40]. (High power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human Tonsil cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40]. (High power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human tonsil cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40], red in A and Mouse anti Human CD21, green in B. C is the merged image with nuclei counterstained blue using DAPI. (Low power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-Fr image

    Immunohistochemistry: Human tonsil cryosection stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40], red in A and Mouse anti Human CD21, green in B. C is the merged image with nuclei counterstained blue using DAPI. (High power).

  • ARG23079 anti-Thrombomodulin antibody [QBEND/40] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human lymph node stained with ARG23079 anti-Thrombomodulin antibody [QBEND/40].